Cytostatic influence of thioproline on peripheral lymphocytes of healthy persons and non-Hodgkin's lymphoma patients.
نویسنده
چکیده
Thiazolidine-4-carboxylic acid (Thioproline, Norgamem) is an agent of possible antitumorigenic effect [1, 2, 7]. This drug seems to induce a "reverse transformation" of pathological cells by restoring contact inhibition in cell cultures [2-6]. No evidence of a cytotoxic effect of Thioproline has so far been observed [2, 4, 9]. In our previous work we demonstrated that Thioproline exerts strong inhibition of DNA synthesis in normal lymphocytes [8]. In this study we present experiments performed in normal as well as in non-Hodgkin's lymphoma (NHL) lymphocytes treated by Thioproline in vitro.
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ورودعنوان ژورنال:
- Haematology and blood transfusion
دوره 32 شماره
صفحات -
تاریخ انتشار 1989